Stalled project: I ordered a replacement keyboard for an Alienware gaming laptop, one that has Cherry MX ULP ultralow profile switches. Very very nice. Then I was going to butcher it into a triptych – cut it in three parts – and bodge a RP2350 controller on each. And figure out some kind of case-something. Tadaa! Actual keyboard – real keyboard – that's actually portable.
> I cannot understand why Jetbrains keep the VM settings as constrained as they do. It's a big difference.
A lot of the things JetBrains does are questionable, particularly the way they write UI applications. One would expect from a company that spawned a widely used JVM language and a JVM IDE that they would know how to write responsive Java UIs, but apparently, they don't. They are doing some really weird stuff like mixing up Skia with Swing, it’s just a big mess. The worst part is that most people will end up thinking Java is the issue. Ironically, Microsoft has done the same to Visual Studio which is incredibly sluggish these days.
Idk what has changed, but I used PyCharm like 10 years ago and it was fine. Way faster than other IDEs in fact. I only stopped cause I switched to vim.
(This is a serious article by a serious researcher. There exists good work on Frontiers in….)
The 5-HT2A receptor is profoundly immunomodulatory. (Acid is arguably a more potent immunomodulator – an antiinflammatory one – than it is psychoactive.) Local inflammation is a thing in injury, "global" inflammation as well – there is strong interplay between cytokines and metabolic/anabolic/catabolic process; Interleukin-6 stimulates osteoclasts which actively break down joint tissue – and neuroinflammation also affects physiology. Muscle tone, blood flow, pulmonary function, and so on.
Ego death happens to be a phenomenon or qualia when you boop that receptor hard. I'm not sure ego death necessary for anything. It might be. Ego death is very intimately related to the individual neuronal state and memory, and inflammation is quite enmeshed with that. (Cf. cortisol.)
I was quite surprised to find that paper! Thank you for… the audience?, for your consideration? It's quietly somewhat maddening that this is on the books and there's so little mention of it.
Like, psychedelics? I'm not a hippie. I'm not into psychedelics. I'm into neuroinflammation, haha
> Inwardly my emotions became numb. I was disconnected from others emotionally. Outwardly my entire vibe shifted from chill to aggressive. I became more argumentative at home. I was looking to dominate others in my interactions.
This is neuroinflammation. This is a way how neuroinflammation presents.
My experience is completely the opposite, of using LLMs to pattern match and cast diagnostic nets.
Is your perspective based on, say, opinionated principle?, or experience?
The benefits are enormous.
The risks; What risks? No diabetic with baseline adult competence is going to drive their insulin-delivery vehicle off a cliff because some app said so.
Type 1 diabetes with the sensors and pump technology that this software being presented here fits to is not Everyman Joe stuff. Someone who can set this up and get this going is already burdened with the kind of analysis that the app can assist with.
> No diabetic with baseline adult competence is going to drive their insulin-delivery vehicle off a cliff because some app said so.
if you can't trust this thing then what is it doing? the implication that people that trust this software do not have adult competency is also confusing.
> Is your perspective based on, say, opinionated principle?, or experience?
your perspective is solely based on recent trauma so I don't know if it is more reliable in any
capacity
Don't do as I say. I'm just a rando from the Internet.
Don't do as the author of the posted software does. Don't do what the software tells you either. But the software can certainly build an informative perspective and suggest patterns and movements in an exquisitely complex disease. Managing T1D with a pump is exhausting.
Second, re. "your perspective is solely based on recent trauma so I don't know if it is more reliable in any capacity"
This kind of statement is far beyond anything bounded by the self-respect of a balanced adult. What the fuck, and who are you?
My ex-fiancée almost died in 2020. We lost an unborn child in IVF due to grave neglect on behalf of healthcare who missed the glaringly obvious Type 1 diabetes she had; They never once checked her blood sugar. You know what I did? I read the literature. I read medicine, I read molecular biology, I read neuroimmunobiology, I read about the placenta and fetal development.
I stood by my fiancée and carried her by hand back to health. She recovered faster than the endocrinologists expected. Her pregnancy was exemplary, fullly intact placental vitals out to 38.5 weeks. Healthcare is in such a bad state that I was forced to interject and argue coolly and adamantly with doctors on several occasions about potentially severe mistakes they were about to make. EVERY SINGLE TIME when I interceded, it was confirmed correct by a second opinion from a senior doctor.
I don't come here speaking from trauma. I come here speaking from grim and serious and confirmed lived experience of stepping in and caring, without any margin for error. Know how you do that? With extreme humility and the utmost care.
Who are you to speak to me like that; I can tell that you know not at all who I am or what I have been tasked with in this life, because then you would not. talk. to me. this way. Okay?
> The risks; What risks? No diabetic with baseline adult competence is going to drive their insulin-delivery vehicle off a cliff because some app said so.
My local physician says otherwise, with respect to facebook posts about dosages. I'm convinced the same applies to LLM generated content with respect to people blindly following the computer.
I ask for your understanding in that I chose to have "baseline adult competence" highly load-bearing in my comment. This does not include people who have only such poor judgement to guide them that they use Facebook posts as input to managing their T1D pump/sensor-based management.
It is entirely possible to beneficially and safely use software like the that which is the topic of the post.
Can you point me to where it explicitly says that this app is not to be consumed by the general public? Or explain how that could even be enforced?
And my entire point was "baseline adult competence" means very little. Competent in what? Technology? Insulin administration? Both? If they're competent in technology but not insulin administration, than this is obviously a bad idea. If they're competent in insulin administration, but not technology, then why would they use it?
We're not even at the point where we can definitely say it's a good idea to surface this information to actual professionals let alone someone with no clinical experience.
It's a bad idea, period. I work with both clinicians and the general public and the idea that this can be responsibility used by either is a pipe dream that only people who work with neither can believe in.
This is as dangerous as people talking together on e.g. Facebook groups. I've seen people give flat out dangerous advice, and other people take it.
Nursed someone back to health and went through a T1D pregnancy and certainly had to work with the clinicians during; Desperately: There is use for this software, and no greater need to bury it or unmake it than it is to bury or unmake Facebook groups or other discussion venues.
In fact, software that actually reads literature and presents perspectives actually derived from plausibility from a scientific basis is in many cases a 100% increase of availability of such a perspective. Doctors – from experience – may not offer that. And forum lore rarely does.
Software that actually reaches into literature – which LLMs do – and presents its perspective with the required framing is arguably a strict improvement to the infohazardous environment of a given patient with a difficult condition like T1 diabetes.
And I ask for this discussion's participants' understanding of the sarcastically wry use of "basic adult competence". It was at once arrogant and caring, and put forward… in something as quasi-serious as a HN discussion. I think that's OK.
> his is as dangerous as people talking together on e.g. Facebook groups. I've seen people give flat out dangerous advice, and other people take it.
Not even remotely close. A large portion of people in the field still don't understand how LLM's work let alone your grandmother on Facebook. They're apples and oranges.
> There is use for this software, and no greater need to bury it or unmake it than it is to bury or unmake Facebook groups or other discussion venues.
Discussion forums are nothing like an LLM. People don't assume the other person on the forum is magic. Again, these are totally different things that have no correlation with each other. People have been in some form of forum for hundreds of thousands of years. They have no experienced a genie that has ingested the entirety of human knowledge. They're just flat out 2 different things.
And you're experience as a single person doesn't mean that experience is universal. I quite literally work with clinicians and patients every day. Clinicians aren't evne sure how to use these tools (with actual clinical knowledge), but yet we're ready to shoot them out to consumers? It's wild.
Of course there is a need to get better info, but that doesn't then follow that the route of that should be an unregulated, unlicensed LLM.
Went through pregnancy with the mother having recently-diagnosed T1 diabetes – just barely not killed by grave neglect on behalf of healthcare due to how badly they missed the diagnosis to begin with.
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