I've known a couple of companies who've worked on server-side ad fetching, stitching ad images together with content images, using only first-party cookies, etc. In both cases it was just too soon - the ad blocking problem wasn't deemed big enough to justify switching over from current ways of doing things.

Ad-blocking blocking (and analytics-blocking blocking) will be a real business someday, but I've never wanted to try it simply because I don't think I could time the market right.