I use Backblaze--$50/year--primarily for photos. My photo drive sits at around 900GB currently. It's entirely in Backblaze, in case it ever explodes and local backups fail.
I let it handle other drives, too, although I exclude my media/music/download/etc drive for simplicity.
Is it encrypted on the client side? That's pretty much my only requirement now, since I have separated my two use cases (backups and syncing). I use encfs on Dropbox for encrypted syncing, and it works great, but I need backups encrypted on the client, and I haven't found anything great and cheap yet.
Actually it is a yes, they cannot decrypt your data as they do not keep your password around. You have to enter it every time you want to restore a file, and it is not saved on their side only used to get the files then thrown away again.
Of course, if you have so sensitive stuff that you cannot accept it ever being on another server in clear text then it still a no on that question.
I let it handle other drives, too, although I exclude my media/music/download/etc drive for simplicity.