Seems to me this weirdly presumptuous post--imagine for a second a stranger pontificating to the world on how your wife would feel about you doing some hypothetical thing--is refuted almost entirely by Graham's lecture & essay "Before the Startup". http://www.paulgraham.com/before.html
He's not telling people unconditionally not to start a startup, but he is very frank about reasons why one shouldn't.
Exposing yourself to the Internet creates a strange sort of voyeurism where you have a personal connection to someone, but that connection tends to be one-way. This creates strange dynamics for prominent bloggers and especially for people on twitch.tv or YouTube where people are giving you life advice and telling you what you should/shouldn't do, or are questioning your actions like they are your close friend, even though you have no idea who they are.
He's not telling people unconditionally not to start a startup, but he is very frank about reasons why one shouldn't.